We are seeking an experienced cancer biologist to help lead our Biology Team. In this position, you will help lead and manage our Biology Team and work closely with our Platform Team in the development of our core drug discovery technology.

Your responsibilities will include phenotypic assay development, establishing pre-clinical in vitro/in vivo studies, performing mechanistic studies on lead drug molecules, spearheading forays into new oncology indications, and grant writing.

About You

High Agency. Initiative, independence, and self-accountability are some of our most valued traits.

Enthusiastic. We love people who are excited about what they are doing and are generally attempting to build a high-energy team.

Intensity and Grit. Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.

Prosocial. We are here to create life-saving medicines for the patients who need it most. You should be, too.

Qualifications & Nice-To-Haves

PhD in Cancer Biology, Cell Biology, or related field
5-7+ years of industry experience
Deep understanding of small-molecule drug discovery and its relationship to human disease
Strong experience with:
Mechanistic studies of cancer cell signaling and PTM analysis
Phenotypic assay development for cancer drug discovery (low to high throughput)
Small molecule drug development campaigns (hit discovery, hit validation, dose-response studies, MOA studies)
Excellent cellular and molecular biology knowledge/experience (cancer cell lines, generation of stable cell lines using lenti/CRISPR systems, IP/pull down assays, RNA-Seq, flow cytometry, plasmid design)
Top-notch written and oral communication skills
Proficiency in:
Managing a team of exceptional scientists and research associates
Target/indication selection
Pre-clinical and IND-enabling studies
Animal models of cancer (GEMM, orthotopic, xenograft models)
Managing CROs for in vivo studies
Grant writing
Nice to have:
Prior experience on teams that have successfully advanced research to the clinic
Familiarity or experience with PROTAC/next-gen IPM technologies
Experience with PPI techniques, e.g., BRET, APEX/BioID, AlphaScreen

About Us

Work Hard/Play Hard. We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we're at work, we're there to get things done, and when we're off, we're really off. 🌴

Strong Communication. We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.

Writing First. We have a "writing-first" culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.

Growth. As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.

Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)

General Proximity

Principal Scientist/Director, Cancer Biology

San Francisco, CAfull-time

Additional questions